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FLASH GENE
Symbol NUP214 contributors: mct/npt - updated : 03-06-2015
HGNC name nucleoporin 214kDa
HGNC id 8064
ASSOCIATED DISORDERS
corresponding disease(s) CAN , IIAE9
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
with DEK in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome
tumoral fusion      
with ABL1 in T-cell acute lymphoblastic leukemia
tumoral fusion      
SET is fused to the C terminus of NUP214, occuring in certain forms of acute myeloid leukemia and inhibiting CRM1-dependent nuclear export
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS