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FLASH GENE
Symbol MSMB contributors: mct/npt/pgu - updated : 15-02-2018
HGNC name microseminoprotein, beta-
HGNC id 7372
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
suppression of MSMB expression promotes anchorage-independent growth of prostate epithelial cells, but not growth of breast epithelial cells
tumoral     --low  
in ovarian cancer with reduced survival
Susceptibility
  • to prostate cancer, HPC13 (OMIM 611928)
  • to spermatogenic failure associated with male infertility
  • Variant & Polymorphism SNP
  • increasing the risk of prostate cancer
  • rs10993994 is the strongest associated variant to risk of prostate cancer
  • rs10993994 associated with risk of spermatogenic failure
  • Candidate gene
    Marker
  • prostate cancer (PC) biomarker
  • Therapy target
    ANIMAL & CELL MODELS