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FLASH GENE
Symbol PVT1 contributors: mct/npt/pgu - updated : 31-08-2016
HGNC name Pvt1 oncogene homolog (mouse)
HGNC id 9709
ASSOCIATED DISORDERS
corresponding disease(s) PVT1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   amplification    
in breast and ovarian cancer associated with reduced survival duration in patients treated with agents that act through apoptotic mechanisms
tumoral fusion      
PVT1-MYC fusion in Group 3 medulloblastoma
tumoral     --over  
in gastric carcinoma promotes the development of multidrug resistance (MDR), suggesting an efficacious target for reversing MDR in gastric cancer therapy
Susceptibility
  • to end-stage renal disease (ESRD) in type 1 diabetes
  • to Hodgkin lymphoma
  • Variant & Polymorphism SNP , other
  • a common haplotype containing the C allele at rs10808565 and the A allele at rs13447075 that was associated with ESRD
  • association between SNP rs2720709 and ESRD (Hanson 2007)
  • SNP increasing the risk of Hodgkin lymphoma
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS