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FLASH GENE
Symbol PENK contributors: mct - updated : 08-09-2015
HGNC name proenkephalin
HGNC id 8831
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
by hypermethylation in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma
constitutional     --over  
in keratinocytes in psoriatic skin
Susceptibility
  • not contributing to the susceptibility of bipolar affective disorder
  • to opioid dependence
  • Variant & Polymorphism other polymorphisms increasing the risk of opioid dependence
    Candidate gene useful indicator of the potential malignancy of epithelial cells of the pancreas
    Marker
  • marker predicting acute kidney injury in cardiac surgery patients
  • enhanced plasma PENK could be a useful, complementary tool to predict short- or long-term clinical outcome after severe traumatic brain injury
  • PENK level may be a useful, complementary tool to predict mortality and functional outcome at 6 months after aneurysmal subarachnoid hemorrhage
  • Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    anti-PENK drugs in addition to current antipsoriatic therapies might be of value in treating this common chronic skin disease
    ANIMAL & CELL MODELS