| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in small cell and non small cell lung carcinoma with poor prognosis and in prostate tumor (benign or carcinoma) | | tumoral
|
|
|
| gain of function
| |
in hepatopcellular carcinoma | | tumoral
|
|
| --other
|
| |
abnormal expression of REST and MYC in neural stem/progenitor cells causes cerebellum-specific tumors by blocking neuronal differentiation and thus maintaining the "stemness" of these cells | | tumoral
| fusion
| translocation
|
|
|
t(8;9)(q24;p13), fusion to PAX5 on chromosome 9, joining MYC to ZCCHC7 and to ZBTB5 exon 2, two genes encoding zinc-finger proteins, in B-cells lymphomas  | | constitutional
|
|
| --over
|
| |
Myc-overexpressing cells have cytokinesis defects, supernumery centrosomes and genomic instability as a consequence of augmented cap-dependent translation | | tumoral
|
|
| --other
|
| |
dysregulation by complex mechanisms is one of the major molecular events in the oncogenesis of plasma cell leukemia | |
