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Symbol MYC contributors: shn/ - updated : 08-07-2018
HGNC name v-myc myelocytomatosis viral oncogene homolog (avian)
HGNC id 7553
corresponding disease(s) MYC
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in small cell and non small cell lung carcinoma with poor prognosis and in prostate tumor (benign or carcinoma)
tumoral       gain of function
in hepatopcellular carcinoma
tumoral     --other  
abnormal expression of REST and MYC in neural stem/progenitor cells causes cerebellum-specific tumors by blocking neuronal differentiation and thus maintaining the "stemness" of these cells
tumoral fusion translocation    
t(8;9)(q24;p13), fusion to PAX5 on chromosome 9, joining MYC to ZCCHC7 and to ZBTB5 exon 2, two genes encoding zinc-finger proteins, in B-cells lymphomas
constitutional     --over  
Myc-overexpressing cells have cytokinesis defects, supernumery centrosomes and genomic instability as a consequence of augmented cap-dependent translation
tumoral     --other  
dysregulation by complex mechanisms is one of the major molecular events in the oncogenesis of plasma cell leukemia
  • to urinary bladder cancer
  • to prostate carcinoma
  • Variant & Polymorphism other polymorphisms increasing the risk of urinary bladder cancer
    Candidate gene
    Therapy target
  • transient inactivation of MYC may be an effective therapy for certain cancers
  • c-Myc-null mice die by embryonic day 10.5 with defects in growth and in cardiac and neural development
  • Myc-induced T cell leukemia in transgenic zebrafish
  • transgenic mice conditionally overexpress Myc in liver cells develop liver tumors and died
  • double-transgenic mice overexpress myc and EIF4E develop lymphoma