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FLASH GENE
Symbol SKP1 contributors: mct - updated : 28-06-2016
HGNC name S-phase kinase-associated protein 1
HGNC id 10899
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   amplification    
with SKP2 (p45), cyclin A/CDK2 in transformed cells
constitutional     --low  
in the substantia nigra pars compacta (SNpc) of post-mortem parkinsonian brains
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
neurologyneurodegenerativeParkinson/dementia Parkinsonism
strategies aimed at increasing the activity or content of SKP1 may represent a novel therapeutic approach that has the potential to treat Parkinson disease
ANIMAL & CELL MODELS
early embryonic lethality and dysregulation of cyclin E(CCNE) in CUL-/-mice