Symbol
| SKP1
| contributors: mct - updated : 28-06-2016
|
HGNC name
| S-phase kinase-associated protein 1
|
HGNC id
| 10899
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
| amplification
|  
|  
|
with SKP2 (p45), cyclin A/CDK2 in transformed cells | constitutional
|  
|  
| --low
|  
|
in the substantia nigra pars compacta (SNpc) of post-mortem parkinsonian brains | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
neurology | neurodegenerative | Parkinson/dementia Parkinsonism | |
strategies aimed at increasing the activity or content of SKP1 may represent a novel therapeutic approach that has the potential to treat Parkinson disease |
| | | |
| early embryonic lethality and dysregulation of cyclin E(CCNE) in CUL-/-mice |