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FLASH GENE
Symbol DEFA6 contributors: mct - updated : 21-01-2015
HGNC name defensin, alpha 6, Paneth cell-specific
HGNC id 2765
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in Crohn disease of the ileum
tumoral     --over  
in colon adenoma the gene expression analysis revealed a 100 fold increased median expression of DEFA6 relative to normal colon tissue
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • expression of DEFA6 preferably can be used as a potential diagnostic marker for adenoma and not as a marker for fully blown carcinoma
  • Therapy target
    ANIMAL & CELL MODELS