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FLASH GENE
Symbol GEM contributors: mct/npt - updated : 16-06-2015
HGNC name GTP binding protein overexpressed in skeletal muscle
HGNC id 4234
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
leads to stress fiber disruption, actin and cell shape remodeling and neurite elongation in interphase cells
constitutional        
loss of GEM leads to misaligned chromosomes and prometaphase delay
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Gem-deficient mice were glucose intolerant and had impaired glucose stimulated insulin secretion