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FLASH GENE
Symbol LEP contributors: mct/pgu - updated : 12-12-2016
HGNC name leptin
HGNC id 6553
ASSOCIATED DISORDERS
corresponding disease(s) OBS1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in Alzheimer disease (AD) patients, and serum levels are inversely correlated to severity of dementia
constitutional     --over  
in placentas of preeclampsia and HELLP syndrome
Susceptibility
  • to obesity
  • common promoter variant associated with changes in the relationship between serum leptin and fat mass in obese girls
  • Variant & Polymorphism SNP
  • 2548 G>A and others
  • obese carriers of common allelic variations had an increased risk to display extreme snacking behavior
  • Candidate gene
    Marker
  • ratios of ADIPOQ/LEP and ADIPOQ/RETN constitute novel predictor factors to explain polycystic ovary syndrome (PCOS)
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    leptin, and potentially PRKAA1 activators, may provide a novel therapeutic approach to AD treatment
    ANIMAL & CELL MODELS