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FLASH GENE
Symbol SMARCA2 contributors: mct/npt/pgu - updated : 21-05-2015
HGNC name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
HGNC id 11098
ASSOCIATED DISORDERS
corresponding disease(s) CSSSCA2 , NKBRS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
in human gastric cancer cell lines
Susceptibility
  • to schizophrenia
  • to lung cancer risk
  • Variant & Polymorphism SNP
  • significantly correlated in the fold changes of gene expression from schizophrenic prefrontal cortex
  • two insertion promoter sequence variants are associated with loss of SMARCA2 expression and lung cancer risk
  • Candidate gene
  • valid marker of gastric oncogenesis
  • Marker
    Therapy target
    ANIMAL & CELL MODELS