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FLASH GENE
Symbol IMPDH1 contributors: mct/pgu - updated : 14-03-2015
HGNC name IMP (inosine monophosphate) dehydrogenase 1
HGNC id 6052
ASSOCIATED DISORDERS
corresponding disease(s) RP10 , LCA11
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
development of malignancy and the growth progression of some tumors
Susceptibility
  • to resistance to immunosuppressive drug, mycophenolic acid (MPA)
  • Variant & Polymorphism SNP increasing the risk of resistance to immunosuppressive drug, mycophenolic acid (MPA)(
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • 17-AAG is able to protect photoreceptor cells form degeneration in the RP10 mouse model by inducing heat shock proteins to reduce the formation of mutant Impdh1 aggregates (