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FLASH GENE
Symbol TEK contributors: mct/pgu - updated : 07-06-2023
HGNC name TEK tyrosine kinase, endothelial
HGNC id 11724
ASSOCIATED DISORDERS
corresponding disease(s) VMCM
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       gain of function
in pulmonary hypertension
constitutional somatic mutation      
cause solitary and multiple sporadic venous malformations
tumoral       gain of function
may be important in modifying the evolution of gliomas during conventional chemotherapy regimens, and open new avenues for the search of more effective therapies to avoid the inevitable brain tumor recurrence
constitutional somatic mutation      
in venous malformations (VM)
constitutional somatic mutation      
in blue rubber bleb nevus syndrome (Bean syndrome)
constitutional     --other  
disruption of TEK/angiopoietin signaling and procoagulant changes in endothelial cells in severe COVID-19
constitutional       loss of function
disruption of the endothelial TEK axis is a sentinel event in septic disseminated intravascular coagulation (DIC)
constitutional     --over  
markedly increased prevalence of endothelial tyrosine kinase receptor (TEK/TIE2)+ macrophages in Alveolar capillary dysplasia (ACD) is a rare lung developmental disorder leading to persistent pulmonary arterial hypertension and fatal outcomes in newborns
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
miscelleaneousvascular 
potential therapeutic targets for venous malformations
immunologyinfectious 
activation of TEK with the small molecule AKB-9778 reversed the prothrombotic state induced by COVID-19 plasma in primary endothelial cells
bloodcoagulation 
targeting TEK may normalize coagulation in inflammatory states while averting the bleeding risks of current DIC therapies
ANIMAL & CELL MODELS
  • peritoneal macrophages from Tie2 knockout mice can inhibit the expression of autophagy-related factors and inhibit the expression of angiogenic factor of VEGFA by activating AMPK signaling pathway