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FLASH GENE
Symbol PMS2 contributors: mct - updated : 05-05-2010
HGNC name PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
HGNC id 9122
ASSOCIATED DISORDERS
corresponding disease(s) HNPCC4 , CMMRD
related resource International Group on Hereditary Non-Polyposis Colorectal Cancer
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
in colon and uterus tumor
Susceptibility to prostate cancer
Variant & Polymorphism SNP , other
  • three SNP causing defective protein-protein interaction with MLH1
  • rare genetic variants that confer a high risk of prostate cancer when mutated
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS