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FLASH GENE

Symbol

RUNX1T1

contributors: mct/npt/pgu - updated : 08-01-2016

HGNC name	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
HGNC id	1535

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     translocation t(8;21)(q22;q22) forming a chimeric fusion protein with RUNX1 (5' - RUNX1 - RUNX1T1 - 3') in acute myeloid leukemia (AML-M2) tumoral fusion       AML1-ETO9a leads to rapid development of leukemia and results in the substantially earlier onset of AML because blocks myeloid cell differentiation at a more immature stage constitutional   translocation     disruption of RUNX1T1 suggest involvement in human brain and heart development tumoral       gain of function of the RUNX1-RUNX1T1 gene set may be an important factor contributing to the etiology of clear cell renal cell carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS