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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

PAPPA

contributors: mct - updated : 23-09-2013

HGNC name	pregnancy-associated plasma protein A, pappalysin 1
HGNC id	8602

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in ovarian carcinoma constitutional     --over   associated with abnormal glucose metabolism and increased risk of atherosclerosis in adult patients with growth hormone deficiency patients

Susceptibility

to coronary disease

Variant & Polymorphism other	the IVS6+95C allele is an independent risk factor for MI

Candidate gene
Marker	circulating levels of PAPPA is an established biomarker in prenatal screening for chromosomal abnormalities
Therapy target

ANIMAL & CELL MODELS