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Symbol HSPA5 contributors: mct/pgu/shn - updated : 04-06-2019
HGNC name heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HGNC id 5238
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
expression correlates with histologic differentiation and favorable prognosis in neuroblastic tumors
tumoral     --over  
in various cancer cells and tumors, including breast, lung, liver, prostate, colon, and gastric cancers, correlating with malignancy, metastasis, and drug resistance
tumoral     --over  
in a variety of tumors and confers drug resistance in both proliferating and dormant cancer cells
constitutional       gain of function
with CASP12 were upregulated in cardiomyocytes in the diastolic heart failure resulting from hypertension
constitutional     --over  
suppresses apoptosis induced by BIK and PMAIP1, either alone or in combination
constitutional     --low  
in the cells expressing expanded polyQ tract-containing proteins
Susceptibility to bipolar disorder
Variant & Polymorphism other promotor polymorphisms may affect the interindividual variability of ER stress response and may confer a genetic risk factor for bipolar disorder
Candidate gene
Therapy target
concomitant use of current chemotherapeutic agents and novel therapies against HSPA5 may offer a powerful dual approach to arrest cancer initiation, progression, and metastasis
suppression HSPA5 through small interfering RNA sensitizes cancer cells to chemotherapeutic drug-mediated cell death and inhibits tumor progression and repression by E2F1 is one of the underlying mechanisms of E2F1-mediated sensitization of cancer cells
disrupting the TDGF1/HSPA5 binding interface blocks oncogenic TDGF1 signaling and may have important therapeutic value in the treatment of cancer
cancerhead and neck 
regulation of the MUL1-HSPA5 axis can be a novel strategy for the treatment of HNC
cytosolic ubiquitin staining is dramatically reduced in GRP78-null Purkinje cells. The mice show retarded growth and severe motor coordination defect by week 5 and cerebellar atrophy by week 13. A novel mouse model of accelerated cerebellar degeneration with basic and clinical applications