Symbol
| PTPN2
| contributors: mct/npt/pgu - updated : 07-12-2015
|
HGNC name
| protein tyrosine phosphatase, non-receptor type 2
|
HGNC id
| 9650
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
| deletion
|  
|  
|
specifically found in T-ALLs with aberrant expression of the TLX1 transcription factor oncogene  | tumoral
|  
|  
| --low
|  
|
sensitizes lymphoid cells to JAK1-mediated transformation and reduces their sensitivity to JAK inhibition | tumoral
|  
|  
| --low
|  
|
in triple-negative breast cancers  | constitutional
|  
|  
|  
| loss of function
|
results in aberrant T-cell differentiation and intestinal dysbiosis similar to those observed in Crohn disease (CD)  | |
Susceptibility
|
to type 1 diabetes to Crohn disease |
Variant & Polymorphism
SNP
| single-nucleotide polymorphisms (SNPs) rs2542151 (PTPN2) associated with Crohn disease  |
|
|
Candidate gene
Marker
Therapy target
| | | |