| Symbol
| PTPN2
| contributors: mct/npt/pgu - updated : 07-12-2015
|
| HGNC name
| protein tyrosine phosphatase, non-receptor type 2
|
| HGNC id
| 9650
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
| deletion
|
|
|
specifically found in T-ALLs with aberrant expression of the TLX1 transcription factor oncogene  | | tumoral
|
|
| --low
|
| |
sensitizes lymphoid cells to JAK1-mediated transformation and reduces their sensitivity to JAK inhibition | | tumoral
|
|
| --low
|
| |
in triple-negative breast cancers | | constitutional
|
|
|
| loss of function
| |
results in aberrant T-cell differentiation and intestinal dysbiosis similar to those observed in Crohn disease (CD) | |
| Susceptibility
|
to type 1 diabetes to Crohn disease |
| Variant & Polymorphism
SNP
| single-nucleotide polymorphisms (SNPs) rs2542151 (PTPN2) associated with Crohn disease |
| 
|
Candidate gene
Marker
Therapy target
|
| | | |