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FLASH GENE
Symbol CD74 contributors: mct/ - updated : 22-06-2016
HGNC name CD74 molecule, major histocompatibility complex, class II invariant chain
HGNC id 1697
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
  • overexpressed in ulcerative colitis
  • low expressed in gastric cancer
  • constitutional     --low  
    leads to altered macrophage activation towards a pro-inflammatory signature and a disturbed crosstalk with trophoblasts
    tumoral     --over  
    CD74, MIF and TLR4 were found to be expressed in gastric cancer and increased significantly in the advanced stage, and were also associated with lymph node metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS