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FLASH GENE
Symbol XRCC4 contributors: mct/pgu - updated : 21-03-2016
HGNC name X-ray repair complementing defective repair in Chinese hamster cells 4
HGNC id 12831
ASSOCIATED DISORDERS
corresponding disease(s) MOPD5
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in synovial sarcoma after SYT-SSX fusion
Susceptibility
  • to myeloma for some htSNPs
  • to glioma
  • to endometriosis
  • Variant & Polymorphism SNP , other
  • increasing the risk of multiple myeloma
  • increasing the risk of glioma
  • XRCC4 G-1394T is a significant SNP in bladder carcinogenesis
  • XRCC4 codon 247*A and XRCC4 promoter -1394*T related genotypes and alleles, but not XRCC4 intron 3 I/D polymorphism, might be associated with endometriosis
  • XRCC4 G-1394T may be responsible for lung carcinogenesis
  • significant association between XRCC4 genotypes with NSCLC risk
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS