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FLASH GENE
Symbol EZR contributors: mct - updated : 30-03-2020
HGNC name ezrin
HGNC id 12691
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in metastatic rhabdomyosarcoma
tumoral     --over  
frequently overexpressed in gastrointestinal stromal tumors, especially those arising from the non-gastric sites
tumoral     --over  
in highly metastatic cancers is probably due to a direct interaction between S100P-ezrin )
tumoral     --over  
contributed to non-small-cell lung cancer progression (
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • might be a potential prognostic marker of non-small-cell lung cancer progression
  • EZR, CLIC5 and PODXL could be likely biological markers to predict the prognosis of hepatocellular carcinoma (HCC) and these proteins participate in migration and invasion processes
  • Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    may represent a novel target for the treatment of Pancreatic Ductal Adenocarcinoma
    cancerreproductiveuterus
    represents a promising target for the development of novel and effective strategies aimed at preventing the progression of cervical cancer
    ANIMAL & CELL MODELS