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FLASH GENE
Symbol NR2F2 contributors: mct/npt - updated : 25-09-2015
HGNC name nuclear receptor subfamily 2, group F, member 2
HGNC id 7976
ASSOCIATED DISORDERS
corresponding disease(s) DEL15QD , DIH1 , VCHD
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
significantly impaired adult neoangiogenesis (Qin 2010)
tumoral       gain of function
upregulated in metastatic prostate cancer, and its higher expression correlated with a worse clinical outcome
Susceptibility to nonsyndromic atrioventricular septal defects (AVSDs)
Variant & Polymorphism other
  • variants in NR2F2 probably contribute to AVSDs and other CHDs during human development
  • Candidate gene for heart defects in del 15q patients
    for isolated congenital diaphragmatic hernia
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    inhibition of NR2F2 may offer a therapeutic approach for anticancer intervention
    cancermetastases 
    . inhibition of NR2F2 suppresses metastases of mammary tumors to the lung
    cancerreproductiveprostate
    is a potential drug target for the intervention of metastatic human prostate cancer
    ANIMAL & CELL MODELS
  • decreased dosage of Nr2f2 in mice has been shown to result in abnormal development of atrioventricular septa
  • mice lacking Coup-tf2 die around E10 due to defects of angiogenesis and heart development