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FLASH GENE
Symbol NT5E contributors: mct/shn - updated : 12-06-2013
HGNC name 5'-nucleotidase, ecto (CD73)
HGNC id 8021
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in melanoma with with a highly invasive phenotype
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
dermatologyskin 
biochemical or biological inhibitors of ENTPD1 and/or NT5E may hold promise in the treatment of dermal fibrosis in diseases such as scleroderma
ANIMAL & CELL MODELS
  • ecto-5'-nucleotidase/CD73-deficient mice have a significantly reduced fall in stop flow pressure and superficial nephron glomerular filtration rate in response to a saturating increase of tubular perfusion flow (Castrop et al, 2004)