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FLASH GENE
Symbol MYB contributors: mct - updated : 14-12-2016
HGNC name v-myb myeloblastosis viral oncogene homolog (avian)
HGNC id 7545
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
contribute to leukemogenesis
tumoral     --over  
at relatively high levels in at least two epithelial tumors: colon and breast cancer
tumoral     --over  
in T cell acute lymphoblastic leukemia
constitutional     --over  
promotes nuclear accumulation of DHRS2, which is able to support P53 stabilization and activation
tumoral fusion translocation    
t(6;9)(q23.3;p22.3) translocation in adenoid cystic carcinomas (ACC) of the breast and head and neck results in fusions encoding chimeric transcripts predominantly consisting of MYB exon 14 linked to the last coding exon(s) of NFIB
constitutional   deletion    
in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression
tumoral fusion      
MYB-GATA1 fusion gene in acute basophilic leukemia
tumoral     --over  
aberrantly overexpressed in pancreatic cancer cells and acts as a key determinant of pancreatic tumour growth and metastasis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target could be a therapeutic target in human T-ALL
ANIMAL & CELL MODELS