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FLASH GENE
Symbol PRDM1 contributors: mct/ - updated : 09-10-2013
HGNC name PR domain containing 1, with ZNF domain
HGNC id 9346
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
deleted in several B-cell non Hodgkin lymphoma and other cancers
tumoral somatic mutation      
in B-cell lymphoma
tumoral     --other  
disruption of homeostatic control by PRDM1 may be an important pathogenetic mechanism for natural killer cell lymphoma
Susceptibility
  • to systemic lupus erythematosus
  • to therapy-induced second malignancies after Hodgkin lymphoma
  • Variant & Polymorphism other
  • variant (rs6568431) identified in an intergenic region between PRDM1 and ATG5 (APG5 autophagy 5-like) associated to to systemic lupus erythematosus
  • variants implicated in the etiology of therapy-induced second malignancies after Hodgkin lymphoma
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in the Prdm1 conditional knockout (CKO) retina, the number of photoreceptor cells was markedly reduced in the differentiated retina