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FLASH GENE
Symbol AFF4 contributors: mct - updated : 21-12-2015
HGNC name AF4/FMR2 family, member 4
HGNC id 17869
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   translocation    
between the Mixed Lineage Leukemia (MLL) and AF4 Family (AFF) member genes, are implicated in leukemia
constitutional     --other  
ectopic expression, repressed HIV-1 LTR-directed RNA Polymerase II transcription, at the level of Tat-transactivation
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
Aff4/Af5q31-null mice display azoospermia as their only phenotype, demonstrating the essential role of this protein in Sertoli cells