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FLASH GENE
Symbol RAN contributors: mct - updated : 15-04-2017
HGNC name RAN, member RAS oncogene family
HGNC id 9846
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       gain of function
coactivation with longer poly-Q AR may contribute to partial androgen sensitivity during the development of Kennedy disease
tumoral     --over  
in the early stages of primary prostate cancer
tumoral     --over  
in high grade serous epithelial ovarian cancers, and its overexpression is associated with a poor prognosis
constitutional     --low  
significantly reduced in the replicative senescence
tumoral     --over  
in pancreatic cancer tissues highly correlated with the histological grade
constitutional     --low  
in Alzheimer disease
tumoral     --low  
in myeloma patients, compared with peripheral blood lymphocytes
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • is a novel biomarker and target molecule for the diagnosis of pancreatic cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may be suitable as a therapeutic target
    cancerdigestivepancreas
    target molecule for the treatment of pancreatic cancer
    cancerlung 
    potential therapeutic target of MYC-driven cancer progression in lung cancers
    cancerreproductivebreast
    potential therapeutic target of MYC-driven cancer progression in breast cancers
    ANIMAL & CELL MODELS