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FLASH GENE
Symbol GADD45A contributors: mct - updated : 17-08-2016
HGNC name growth arrest and DNA-damage-inducible, alpha
HGNC id 4095
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in preeclamptic placentas compared to non-preeclamptic controls, and correlate with elevated sFLT1
constitutional     --over  
in atrophying muscles
Susceptibility to breast cancer
Variant & Polymorphism
Candidate gene
Marker
  • may provide a unique prognostic marker of chronic myelogenous leukemia progression
  • serum GADD45A methylation in combination with PSA and fcDNA level was useful in distinguishing benign from prostate cancer patients
  • Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    inhibition of GADD45A might be a therapeutic strategy for diabetic foot ulcers
    ANIMAL & CELL MODELS