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FLASH GENE
Symbol CTNNA1 contributors: mct - updated : 21-02-2015
HGNC name catenin (cadherin-associated protein), alpha 1, 102kDa
HGNC id 2509
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral somatic mutation     loss of function
loss of function by somatic mutation in lung, prostate, ovarian colon cancer cell lines
tumoral     --low  
by hypermethylation, more common in AML patients with 5q deletion than those without 5q deletion
Susceptibility
Variant & Polymorphism
Candidate gene loss of expression of the alpha-catenin tumor suppressor in hematopoietic stem cells may provide a growth advantage that contributes to human MDS or AML with del(5q)
Marker
Therapy target
ANIMAL & CELL MODELS