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FLASH GENE
Symbol AFDN contributors: mct - updated : 06-02-2018
HGNC name afadin
HGNC id 7137
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
fused with HRX (MLL), in acute myeloid leukemia with translocation t(6;11)(q27;q23) in a VNTR rich region (see ST8)
tumoral     --low  
in tumors correlates with high tumor size and poor metastasis-free survival in patients
tumoral     --low  
in Pancreatic cancer
constitutional   deletion    
causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS