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FLASH GENE
Symbol SLC9A3 contributors: mct/pgu - updated : 11-10-2018
HGNC name solute carrier family 9 (sodium/hydrogen exchanger), isoform 3
HGNC id 11073
ASSOCIATED DISORDERS
corresponding disease(s) DIAR8
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in Barrett esophagus
tumoral   amplification    
in early stages of non-small cell lung cancer
constitutional     --low  
in patients with ulcerative colitis
Susceptibility
  • to the sudden infant death syndrome (SIDS)
  • to preeclampsia
  • Variant & Polymorphism other
  • the level of SLC9A3 expression in brainstem tissue may contribute to the vulnerability of infants for SIDS
  • Rs4957061 in SLC9A3 was significantly associated with a reduced risk of preeclampsia in whites
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • depleted Slc9a3 in male mice causes infertility due to the abnormal dilated lumen of the rete testis and efferent ductules
  • Cftr expression was dramatically decreased in the epididymis and vas deferens of Slc9a3 knockout mice