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FLASH GENE

Symbol

SLC9A3

contributors: mct/pgu - updated : 11-10-2018

HGNC name	solute carrier family 9 (sodium/hydrogen exchanger), isoform 3
HGNC id	11073

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DIAR8

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in Barrett esophagus tumoral   amplification     in early stages of non-small cell lung cancer constitutional     --low   in patients with ulcerative colitis

Susceptibility

to the sudden infant death syndrome (SIDS) to preeclampsia

Variant & Polymorphism other	the level of SLC9A3 expression in brainstem tissue may contribute to the vulnerability of infants for SIDS
	Rs4957061 in SLC9A3 was significantly associated with a reduced risk of preeclampsia in whites

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	depleted Slc9a3 in male mice causes infertility due to the abnormal dilated lumen of the rete testis and efferent ductules
	Cftr expression was dramatically decreased in the epididymis and vas deferens of Slc9a3 knockout mice