Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol POU5F1 contributors: mct/ - updated : 11-09-2016
HGNC name POU class 5 homeobox 1
HGNC id 9221
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       gain of function
differentially up-regulated in germ cells seminomas
tumoral     --over  
in carcinoma in situ/gonadoblastoma, seminomas/germinoma/dysgerminoma, and embryonal carcinoma undifferentiated, and in breast cancer
tumoral fusion      
wirh EWSR1 in t(6;22)(p21;q12) associated with bone and soft-tissue tumours resulting in a chimaeric molecule fusing the NTD (N-terminal domain) of the EWSR1 to the CTD (C-terminal domain) of POU5F1 embryonic gene
Susceptibility to psoriasis
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestiveliver
co-suppression of POU5F1 and BIRC5 is potentially beneficial for HCC treatment
ANIMAL & CELL MODELS