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FLASH GENE
Symbol GLO1 contributors: mct - updated : 06-11-2010
HGNC name glyoxalase I
HGNC id 4323
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   amplification    
in breast cancer, small cell lung cancer, acute myeloid leukemia, sarcoma
tumoral     --over  
in melanomas
constitutional     --low  
observed in major depressive and bipolar disorder patients in a current depressive state, as compared with healthy control subjects
tumoral     --over  
in kidney tumors
Susceptibility
  • to autism
  • to breast cancer
  • Variant & Polymorphism SNP , other
  • C419A is a predisposing factor for autism
  • Glu111Ala polymorphism associated with breast cancer
  • Candidate gene
    Marker
    Therapy target
  • may represent a useful target for therapy in cancers with GLO1 amplification
  • ANIMAL & CELL MODELS