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FLASH GENE
Symbol FLI1 contributors: mct - updated : 18-05-2015
HGNC name Friend leukemia virus integration 1
HGNC id 3749
ASSOCIATED DISORDERS
corresponding disease(s) TCDM , DEL11QD
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in acute myeloid leukemia
constitutional     --low  
by heavy methylation of the CpG islands in the promoter region was demonstrated in SSc scleroderma (systemic sclerosis) fibroblasts and skin biopsy specimens (epigenetic mechanisms may mediate the fibrotic manifestations of SSc)
tumoral fusion      
with EWSR1, t(11;22)(q24;q12) in Ewing sarcoma, cancer-specific molecule that binds to RHA essential for the function of EWS-FLI1 (Erkizan 2009)
tumoral     --low  
in in metastatic melanoma (Torlakovic 2008)
tumoral fusion      
fusion of SLC45A3 exon 1 with FLI1 exon 3 in prostate cancer
tumoral     --other  
deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma
constitutional     --over  
in 5q- syndrome protects megakaryocytic cells from ribosomal stress contrary to erythroid cells and contributes to effective though dysplastic megakaryopoiesis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • potential prognostic marker in ovarian cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    Small molecules that disable EWS-FLI1 function with minimal toxicity, in particular sparing hematopoetic stem cells, could potentially provide a valuable adjuvant therapy for patients with Ewing sarcoma family tumors
    cancerreproductiveovary
    potential prognostic marker and therapeutic molecular target in ovarian cancer
    ANIMAL & CELL MODELS
    hemorrhage impaired hematopoiesis and lethality in mouse embryo with a targetted disruption of Fli1