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FLASH GENE
Symbol TFF1 contributors: mct - updated : 09-11-2015
HGNC name trefoil factor 1
HGNC id 11755
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   LOH    
in primary gastric cancer
tumoral       loss of function
in breast (tract, digestive) cancer, and some digestive tumors (stomach, pancreas, biliary tract)
tumoral     --low  
in gastric tumors in which tumors exhibited overexpression of CEBPB
tumoral     --over  
by hypomethylation of the promoter/enhancer region, significantly lower in prostate carcinoma compared to benign prostatic hyperplasia
tumoral     --low  
TFF1 expression is significantly downregulated in gastric cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker overexpression and promoter hypomethylation of trefoil factors may serve as biomarkers in prostate carcinoma
Therapy target
SystemTypeDisorderPubmed
cancerreproductivebreast
Functional antagonism of TFF1 can therefore be considered as a novel therapeutic strategy for mammary carcinoma
ANIMAL & CELL MODELS