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FLASH GENE
Symbol SRD5A2 contributors: mct/npt - updated : 01-07-2008
HGNC name steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
HGNC id 11285
ASSOCIATED DISORDERS
corresponding disease(s) PPSH
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral somatic mutation      
in the prostate cancer in progression
Susceptibility
  • to prostate cancer
  • to hypospadias or micropenis
  • Variant & Polymorphism SNP , other
  • mutation ala-49-thr increase the risk in african american men
  • SNP V89L increases the risk of hypospadias
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS