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FLASH GENE
Symbol DRD5 contributors: mct - updated : 16-09-2015
HGNC name dopamine receptor D5
HGNC id 3026
ASSOCIATED DISORDERS
corresponding disease(s) DTPC
Susceptibility
  • to blepharospasm (OMIM 606798)
  • to attention deficit hyperactivity disorder (Adhd) with preferential transmission of paternal alleles
  • to schizophrenia, not bipolar disorder
  • Variant & Polymorphism repeat , other
  • allele 2 of dinucleotide repeat significantly associated with blepharospasm
  • variant in DRD5 may affect age at onset for ADHD
  • Candidate gene for primary cervical dystonia (allele 4 of (CT/GT/GA)n microsatellite is associated with cervical dystonia)
    Marker
    Therapy target
  • therapy for hypertension might be optimized by designing compounds that can target the AGTR1 and DRD5
  • ANIMAL & CELL MODELS