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FLASH GENE
Symbol YWHAH contributors: mct/npt - updated : 27-01-2021
HGNC name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
HGNC id 12853
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in synovial fluid from patients with joint inflammation
tumoral   deletion    
with DEPDC5, C22ORF24, in glioblastomas
constitutional     --over  
significantly higher in patients in patients rheumatoid arthritis with radiographically assessed joint damage and in those who had radiographic progressionwith radiographically assessed joint damage and in those who had radiographic progression
Susceptibility to rs2246704 was associated with BP (bipolar disorder)
Variant & Polymorphism SNP rs2246704 was associated with bipolar disorder
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • differential expression of YWHAH, YWHAQ throughout brain regions of rats with insulin resistance
  • 14-3-3eta-deficient mice displayed auditory impairment accompanied by cochlear hair cells' degeneration