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FLASH GENE
Symbol EIF4E contributors: mct - updated : 20-10-2018
HGNC name eukaryotic translation initiation factor 4E
HGNC id 3287
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   amplification    
in head and neck squamous cell carcinomas
tumoral     --over  
leads to increased tumours and metastases
tumoral     --other  
aberrant expression promotes tumorigenesis and has been implicated in cancer development and progression
Susceptibility to autism
Variant & Polymorphism insertion/deletion in autism, single nucleotide insertion at position -25 in the basal element of the EIF4E promoter, enhancing binding of a nuclear factor and EIF4E promoter activity
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerhemopathy 
therapies targeting eIF4E in the clinic, including the use of a physical mimic of the m7G cap ribavirin in refractory acute myeloid leukaemias (AMLs) in a phase I/II clinical trial
psychiatryautism 
pharmacological manipulation of EIF4E may provide therapeutic benefit for those with autism caused by disturbance of the converging pathways controlling EIF4E activity
cancer  
EIF4E phosphorylation pathway is a potential therapeutic target for cancer and chemical compounds that prevent the phosphorylation of EIF4E could act as anticancer drugs
ANIMAL & CELL MODELS