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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

EIF4E

contributors: mct - updated : 20-10-2018

HGNC name	eukaryotic translation initiation factor 4E
HGNC id	3287

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in head and neck squamous cell carcinomas tumoral     --over   leads to increased tumours and metastases tumoral     --other   aberrant expression promotes tumorigenesis and has been implicated in cancer development and progression

Susceptibility

to autism

Variant & Polymorphism insertion/deletion	in autism, single nucleotide insertion at position -25 in the basal element of the EIF4E promoter, enhancing binding of a nuclear factor and EIF4E promoter activity

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   therapies targeting eIF4E in the clinic, including the use of a physical mimic of the m7G cap ribavirin in refractory acute myeloid leukaemias (AMLs) in a phase I/II clinical trial psychiatry autism   pharmacological manipulation of EIF4E may provide therapeutic benefit for those with autism caused by disturbance of the converging pathways controlling EIF4E activity cancer     EIF4E phosphorylation pathway is a potential therapeutic target for cancer and chemical compounds that prevent the phosphorylation of EIF4E could act as anticancer drugs

ANIMAL & CELL MODELS