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FLASH GENE
Symbol LMO2 contributors: mct - updated : 10-09-2016
HGNC name LIM domain only 2 (rhombotin-like 1)
HGNC id 6642
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   translocation    
acute lymphoblastic leukemia (T-ALL) with translocations t(11;14)(p13;q11), t(7;11)(p35;p13)
tumoral       loss of function
in renal clear cell carcinomas with poor prognosis
tumoral fusion      
t(14;18)/IGH-BCL2 fusion in diffuse large B-cell lymphoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker promising marker for predicting a better prognosis in pancreatic cancer
Therapy target
SystemTypeDisorderPubmed
cancerhemopathy 
assembly of LMO2 into complexes, via direct LDB1 interaction, is a potential molecular target that could be exploited in LMO2-driven leukemias resistant to existing chemotherapy regimens
ANIMAL & CELL MODELS