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FLASH GENE
Symbol PTMA contributors: mct - updated : 09-11-2016
HGNC name prothymosin, alpha (gene sequence 28)
HGNC id 9623
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in gastric adenocarcinoma
constitutional     --over  
in Alzheimer Disease
tumoral     --over  
in several human malignancies including hepatocellular carcinoma (HCC)
tumoral     --over  
by hypomethylation in gastrointestinal tumors when compared with the peritumoral tissue
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • could be used as an immunohistochemical biomarker in hepatocellular carcinoma to detect patients with a high risk of recurrence
  • assessment of both PTMA and mutant TP53 expression can help predict colon cancer prognosis
  • Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    is a potential novel therapeutic target for type 2 diabetes
    respiratoryCF (mucoviscidosis) 
    has strong potential to be an efficacious single-molecule-based therapeutic agent for CF
    ANIMAL & CELL MODELS
    inducing transformation of rodent fibroblasts in vitro