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FLASH GENE
Symbol PPP1R3C contributors: mct - updated : 30-05-2016
HGNC name protein phosphatase 1 regulatory subunit 3C
HGNC id 9293
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
significantly hypermethylated in Colorectal cancer tissues and colon cancer cell lines
Susceptibility
  • to a milder phenotype in Lafora disease
  • Variant & Polymorphism other
  • a PPP1R3C variant contributes to a milder phenotype in Lafora disease
  • Candidate gene
    Marker
  • PPP1R3C methylation or its combined use of EFHD1 methylation was highly positive in colorectal cancer (CRC) plasma samples, and they might be useful in detection of CRC, especially for early-stage CRCs
  • Therapy target
    ANIMAL & CELL MODELS