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FLASH GENE
Symbol VPS37A contributors: shn - updated : 14-11-2015
HGNC name vacuolar protein sorting 37 homolog A (S. cerevisiae)
HGNC id 24928
ASSOCIATED DISORDERS
corresponding disease(s) SPG53
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • low HCRP1 expression was found to be of adverse prognostic significance in patients with oral and oropharyngeal squamous cell carcinoma
  • Therapy target
    ANIMAL & CELL MODELS
  • overexpression of HCRP1 (Vps37A) significantly inhibited both anchorage-dependent and anchorage-independent cell growth in vitro
  • knock down of the expression of HCRP1 gene by shRNA in hepatocellular carcinoma cell line BEL-7404 result in the cell growth greatly enhanced
  • Vps37A morpholino-injected zebrafish showed striking and significant loss of motility