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FLASH GENE
Symbol TET3 contributors: mct - updated : 25-02-2020
HGNC name tet oncogene family member 3
HGNC id 28313
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       gain of function
DNA demethylase TET3 is anomalously upregulated in fibrotic livers
Susceptibility to Systemic lupus erythematosus (SLE)
Variant & Polymorphism SNP , other multiple independent SNPs increasing the risk of SLE
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
digestiveliver 
inhibiting TET3 may represent a therapeutic strategy for liver fibrosis and perhaps other fibrotic diseases
ANIMAL & CELL MODELS
  • female mice depleted of Tet3 in the germ line show severely reduced fecundity and their heterozygous mutant offspring lacking maternal Tet3 suffer an increased incidence of developmental failure