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Symbol GYPA contributors: mct - updated : 28-11-2018
HGNC name glycophorin A (MNS blood group)
HGNC id 4702
ASSOCIATED DISORDERS
corresponding disease(s) MNS
related resource Blood Group Antigen Mutation Database
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
is a host defense mechanism against rotavirus infection
Susceptibility
  • to variable risk of severe malaria
  • Variant & Polymorphism other
  • stone (Sta) variant antigen associated either with a splicing mutation of GPA or a hybrid formation between GYPA and GYPB or between GYPA and GPYE
  • serologically distinct blood group antigen known as Dantu, reduces the risk of severe malaria by 40p100 and has recently increased in frequency in est Africa
  • DUP4 variant Dantu confers a clinically important protective effect, with carriers &
  • 8764;40p100 less likely to develop cerebral malaria
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS