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FLASH GENE
Symbol SLC2A2 contributors: mct - updated : 28-05-2014
HGNC name solute carrier family 2 (facilitated glucose transporter), member 2
HGNC id 11006
ASSOCIATED DISORDERS
corresponding disease(s) FBIS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation     loss of function
biallelic SLC2A2 inactivation causes lethal neonatal diabetes
Susceptibility
Variant & Polymorphism SNP
  • are associated with the conversion from impaired glucose tolerance to type 2 diabetes
  • polymorphisms at positions -269, -44, or + 103 may affect GLUT2 gene transcription, possibly associated with reduced expression of the GLUT2 gene in NIDDM patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    homozygous mice deficient in GLUT2 are hyperglycemic and relatively hypoinsulinemic and have elevated plasma levels of glucagon, free fatty acids, and beta-hydroxybutyrate