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FLASH GENE
Symbol GLI2 contributors: mct - updated : 06-03-2015
HGNC name GLI family zinc finger 2
HGNC id 4318
ASSOCIATED DISORDERS
corresponding disease(s) HPE9
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
loss of function mutations in pituitary anomalies and holoprosencephaly-like features
tumoral     --over  
overexpression of MAP3K10 resulted in upregulation of GLI1 and GLI2 in pancreatic ductal adenocarcinoma (PDAC) cells
tumoral     --other  
dysregulation of HH/GLI1 signaling disrupts tissue homeostasis and causes basal cell carcinoma (BCC)
tumoral somatic mutation      
in hypothalamic hamartoma with gelastic epilepsy
Susceptibility for cleft lip/palate
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerreproductiveprostate
may potentially become an attractive therapeutic target for the treatment of prostate cancer
ANIMAL & CELL MODELS