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FLASH GENE
Symbol TRIM72 contributors: mct/npt/shn - updated : 20-03-2017
HGNC name tripartite motif-containing 72
HGNC id 32671
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene could be a new candidate for the diagnosis and treatment of patients with Brody syndrome
Marker
Therapy target
SystemTypeDisorderPubmed
neuromuscularmyopathy 
great potential for the use of recombinant TRIM72 in treating muscular dystrophy and other diseases in which compromised membrane integrity contributes to the disease
cardiovascularcardiomyopathy 
. membrane reparative function provides an entirely new model for potential therapy of muscle and cardiovascular diseases, including muscular dystrophy, cardiomyopathy and age-related muscle wasting
neuromuscularmyopathy 
. membrane reparative function provides an entirely new model for potential therapy of muscle and cardiovascular diseases, including muscular dystrophy, cardiomyopathy and age-related muscle wasting
diabetemetabolic syndrom 
novel therapeutic target for treating metabolic disorders and associated cardiovascular complications
ANIMAL & CELL MODELS
  • mice null for TRIM72 show progressive myopathy and reduced exercise capability, associated with defective membrane-repair capacity
  • remarkable defects in skin architecture and collagen overproduction are observed in mg53(-/-) mice, and these animals display delayed wound healing and abnormal scarrin