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FLASH GENE
Symbol SPRTN contributors: mct - updated : 20-06-2017
HGNC name SprT-like N-terminal domain
HGNC id 25356
ASSOCIATED DISORDERS
corresponding disease(s) RJALS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
results in failure to repair DNA-protein crosslinks (DPCs) and hypersensitivity to DPC-inducing agents
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • hypomorphic mice with low amounts of Spartan are viable, and are growth retarded and develop cataracts, lordokyphosis and cachexia at a young age