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FLASH GENE
Symbol CCND1 contributors: mct/ - updated : 02-08-2017
HGNC name cyclin D1
HGNC id 1582
ASSOCIATED DISORDERS
corresponding disease(s) BCL1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
fused with TACSTD2 in cancer cells, fused with Igh in t(11;14) (q13;q32)
tumoral   amplification    
amplified in mantle cell lymphoma(same as BCL1, D11S287E), endometrial cancer
tumoral     --low  
in T-cell leukemia
tumoral   translocation    
t(6;11)(p21;q13), t(1;11)(p13;q13), t(7;11)(q11.2;q13), and t(5;11)(q35; q13) in renal oncocytoma
tumoral     --over  
in parathyroid adenoma, breast (stimulatory effect of estradiol and prolactin) carcinoma
tumoral   amplification    
coamplified with SHANK2, and CTT1 in oral squamous cell carcinoma
tumoral   deletion    
deletion in mantle cell lymphoma, associated with increased proliferation rate and shorter survival
tumoral   translocation    
in parathyroid adenomas
tumoral   amplification    
in breast cancer, alone or with PPFIA1
constitutional     --over  
perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells
Susceptibility
  • to colorectal carcinoma (non polyposis)
  • to lung cancer in smokers from north India
  • to HELLP syndrome
  • Variant & Polymorphism
  • polymorphism modifying the age at onset of colorectal cancer
  • A870G gene polymorphisms may increase the risk of lung cancer in smokers from north India
  • Candidate gene polymorphisms N363S associated with the development of HELLP syndrome
    Marker
  • biomarker for thyroid cancer exhibiting differences in the correlation coefficients between benign and malignant samples that indicate its discriminatory power
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    targeting CCND1 may be beneficial also in retinoblastoma-negative cancers which are currently thought to be unaffected by CCND1 inhibition
    ANIMAL & CELL MODELS