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FLASH GENE
Symbol DACT3 contributors: mct - updated : 20-06-2012
HGNC name dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
HGNC id 30745
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
transcriptionally repressed in colorectal cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestivecolon
potential strategy for therapeutic control of Wnt/beta-catenin signaling in colorectal cancer
ANIMAL & CELL MODELS
  • adult Dapper3-/- mice exhibited a mild reduction in body weight compared with their wild-type littermates, suggesting a functional role of Dapper3 in postnatal growth